1051 Differentiation induces IL-33 gene expression in mouse keratinocytes
نویسندگان
چکیده
IL-33 is a cytokine from the IL-1 family constitutively expressed in epidermis, which has dual-role as chromatin-associated protein keratinocytes and acts pro-inflammatory when released cells. We have investigated gene expression wt mouse keratinocytes. found that mRNA was at basal level primary Interestingly, we observed significantly increased upon keratinocyte differentiation vitro. then assessed stimulation of Our results show does not respond to TNF, IFNγ or IFNα In contrast, resulted significant increase differentiated conclusion, our suggest unlocks renders it sensitive modulation by exogenous stimuli.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.1062